174 , 175 Biallelic loss of function mutations in IFT74 were previously reported to induce BBS with a clear phenotype of obesity, polydactyly, retinal dystrophy, and intellectual disability
Jaeken J, Detheux M, Van Maldergem L, Foulon M, Carchon H, Van Schaftingen E (1996) 3-Phosphoglycerate dehydrogenase deficiency: an inborn error of serine biosynthesis
HO-1 is a stress-induced, anti-inflammatory, immune-modulatory, and cyto-protective enzyme that degrades heme into carbon monoxide, free iron, and biliverdin 47 , consequently, the virus-induced HMRD could compromise host innate and adaptive immune responses
Immortalized cell lines are popular tools to study drug hepatotoxicity because they are cost effective, readily available as cryopreserved cells, can be of human origin and generally show robust proliferation
In supplement form, it is used by healthy adults to support general wellness, particularly in areas like digestive balance, mobility, and overall tissue function
